Abstract: We will discuss SoC design challenges and opportunities for smart and secure cyberphysical systems in the emerging world of IoT, focusing on two distinct areas: (1) how to deliver uncompromising performance and user experience while minimizing energy consumption, and (2) how to provide cryptographic-quality “roots of trust” in silicon and resistance to physical side channel attacks with minimal overhead. We will present SoC designs that span a wide range of performance and power across diverse platforms and workloads, and achieve robust near-threshold-voltage (NTV) operation in nanoscale CMOS. We will discuss techniques to overcome the challenges posed by device parameter variations, supply noises, temperature excursions, aging-induced degradations, workload and activity changes, and reliability considerations. True Random Number Generator (TRNG) and Physically Unclonable Function (PUF) circuits, the two critical silicon building blocks for generating dynamic and static entropy for encryption keys and digital fingerprints, respectively, will be presented. We will also dis-cuss power and electromagnetic physical side-channel-attack detection and mitigation techniques for enabling robust hardware security.