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WuXi AppTec’s DNA Encoded Library (DEL) service is a cutting-edge hit identification and optimization platform using an affinity-based selection method against DNA-Encoded small molecule libraries. The WuXi DEL collections in their entirety consist of more than 90 billion synthetic compounds, and the list continues to grow. With advanced bioinformatics systems to optimize client involvement in making collective decisions, WuXi offers proven success with nano-molar hits in various target classes and flexible business models to accommodate different needs.
One of these business models is DELight, WuXi’s self-serve product that gives researchers direct access to a collection of more than eight billion compounds. Through the DELight service package, WuXi provides a DEL kit and a user manual/protocols document to the research organization. Upon receipt of the kit, the researcher performs affinity selection according to the protocol and returns the sample to WuXi. WuXi then completes analysis such as PCR amplification, qPCR determination, purification and NGS (Next Generation Sequencing). A summary report (excluding structural and DNA sequence information) will be provided back to the researcher, who will make informed decision on follow up actions based on the selection results.