Long acting injectables (LAI) have been around for decades for the delivery of small molecules and peptides to treat chronic and site-specific diseases. However, when it comes to more sensitive biological therapeutics the classical polylactide and polylactide/glycolide based systems suffer from several limitations (e.g. uncontrolled release kinetics, in situ pH drop, protein degradation) making them unsuitable. The SynBiosys® biodegradable polymeric microparticle technology combines all the features required for LAI formulations for biologics. In two case studies we will showcase sustained release formulations for peptides and proteins and demonstrate their potential via extensive in vitro and in vivo characterization.
Director Liquid Formulation R&D
Merck KGaA, Darmstadt, Germany
Tanja Henzler studied Biology in Tübingen and received her PhD in Virology at the Ruprechts Karls University Heidelberg. In 2002 she joined Merck KGaA, Darmstadt, Germany. Tanja Henzler has a focus in protein characterization and protein analytics. After evaluating new technologies for the Life Science part of the company, she was coordinating an interdisciplinary and cross-divisional innovation project. She is now leading the group Liquid Formulation R&D within Life Science/Process Solutions focusing on protein stability and Controlled Release of Biomolecules.
Chief Technology Officer
Rob Steendam, PhD, is co-founder and Chief Technology Officer at InnoCore Pharmaceuticals, a biopharmaceutical drug delivery company specialized in the development of long-acting and minimally invasive injectable drug delivery products for the treatment of chronic and site-specific diseases. He is an inventor of several patents and co-author of multiple peer-reviewed articles related to biodegradable multi-block copolymers and their application in long-acting injectable drug delivery formulations and drug eluting implants. He holds a master degree in Polymer Sciences and a PhD in Pharmaceutical Technology and Biopharmacy, both from the University of Groningen in The Netherlands.