Fundamentals of Spray-Dried Dispersion Technology


Current estimates indicate that more than 70% of new chemical entities require solubilization technology to achieve efficacious plasma exposure. Amorphous solid dispersion technology is a leading approach to improve solubility and dissolution rate of these insoluble compounds by providing a supersaturated concentration of drug in the gastrointestinal environment, which often translates to rapid absorption and improved bioavailability. Amorphous solid dispersions are typically prepared by using hot-melt extrusion or spray drying processes. This webinar will focus on the fundamentals of formulating and processing of spray-dried dispersions, including stability assessment, in-vitro performance, and downstream manufacturability.

In this webinar, experts will discuss:

  • Key parameters that indicate amorphous dispersions and specifically spray dry dispersions as an optimal enabling approach.
  • How the spray drying process can be scaled from tens of milligrams to metric tons.
  • Best practices for formulation screening and evaluation of stability, performance, and manufacturability of spray-dried dispersions.
  • Methodologies and tools for spray drying process development and scale-up through clinical supply and commercial manufacturing.


Key Learning Objectives

Develop an appreciation of key factors leading to the use of spray-dried dispersion technology
Understand the advantages and range of spray-dried dispersions and spray drying technology
Learn the fundamentals of spray-dried dispersion formulation selection, process development, and scale-up


Who Should Attend

Large pharma, mid-size pharma, biotech companies
Product development group leaders and formulators, technical and engineering positions involved in scale-up and manufacturing of oral solid dosage forms


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