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ACS Publications presents: Ion Mobility Derived Collision Cross Sections to Support Metabolomics and Lipidomics

Metabolomics and lipidomics are rapidly evolving analytical approaches to identify metabolites and lipids of biological and medical interest. In this webinar, Giuseppe Paglia, Head of Metabolomics at the Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata - the lead author of an important paper published in March 2014 in Analytical Chemistry -- discusses the use of ion mobility as a tool to aid metabolite and lipid identification and improve the specificity of analysis.

Ion mobility allows for the measurement of the rotationally-averaged collision cross section (CCS), which provides information about the ionic shape of a molecule in the gas phase. The CCS value is a unique physicochemical property of a molecule and can be used along with retention time and mass-to-charge ratio (m/z) to help resolve and identify lipids and metabolites in biological samples. Current software solutions allow for the easy calculation of CCS and integration of this information in a database search. Finally, he will also show examples in which adding CCS data to searchable metabolomics/lipidomics databases increases the specificity of analysis and the identification confidence compared to traditional analytical approaches.

The first 400 registrants of this webinar will receive a digital reprint of the paper Ion Mobility Derived Collision Cross Sections to Support Metabolomics Applications, published in Analytical Chemistry in March 2014. The webinar will also include a 15 minute Q&A session with the speaker and Giuseppe Astarita, Ph.D., Principal Scientist in the Metabolic Phenotyping - Health Sciences division at Waters Corporation. This webinar is underwritten with support from Nonlinear Dynamics, a subsidiary of the Waters Corporation.

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Overview


Title: ACS Publications presents: Ion Mobility Derived Collision Cross Sections to Support Metabolomics and Lipidomics

Date: Wednesday, October 15, 2014

Time: USA 8:00 a.m. PDT / 11:00 a.m. EDT / 16:00 BST

Duration: 60 minutes including Q&A

Speakers


Giuseppe Paglia
Head of Metabolomics, Istituto Zooprofilattico
Sperimentale della Puglia e della Basilicata


Moderator
Tamara Hanna

Acquisitions Editor
Journals Publishing Group




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