Rapid Characterization of Antibody Biotherapeutics Using Middle-Up (Subunit) Analysis

This webcast was recorded on September 10, 2014.

OVERVIEW

This presentation will highlight examples from leading biopharmaceutical companies of ofthe characterization of therapeutic proteins and antibodies using the latest enzymes and UHR-qTOF technology. Application of this new approach enables the analysis of therapeutic antibodies with the minimally invasive technique known as middle-up (subunit) analysis. The latest enzymes and LC–MS technologies have the advantage of being:

- Less time consuming (30 minute digests)
- Virtually free of artifacts (single enzyme digest)
- High-resolution (single amino acid substitutions, including deamidations, can be detected by the latest TOF technologies).

Case studies on this workflow implementation will be discussed.
SPEAKERS

Dr. Lisa Marzilli
Senior Principal Scientist and Group Leader
Pfizer

Fredrik Olsson, MSc.
Director of Operations
Genovis AB

Dr. Jason S. Wood
Market Area Manager
Bio/Pharmaceuticals

Moderator
Meg L'Heureux

Managing Editor
LCGC



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