High Resolution MS Screening and Quantitation Method for Contaminants in Dietary Supplements

This webcast was recorded on April 10, 2014.

The use of herbal dietary supplements has significantly increased in recent decades. One of the main factors leading to this trend is that consumers assume the use of herbal dietary supplements to be a safe and natural alternative to traditional medical treatments. The major safety and authenticity issues related to herbal dietary supplements include the accidental or intentional presence of natural compounds with toxic effects, the presence of synthetic pharmaceuticals added as adulterants, and potential interaction of some natural components with prescription drugs. Recently, a number of poisonings by plant toxins from herbal dietary supplements have been reported.

In the current work, an ultra-high performance–quadrupole-Orbitrap mass spectrometry-based method was developed, optimized, and validated for simultaneous screening and quantitation of pharmaceuticals and plant toxins and metabolites in 30 herbal dietary supplements. The high resolution spectra recorded in full MS–data dependent MS–MS acquisition mode provided a high degree of confidence in identifying the analytes.

The optimization of sample preparation, chromatographic separation, and mass spectrometric detection, as well as requirements for confirmation of analyte identity and strategies for quantitation will be discussed in the presentation.


Laura Bush

Editorial Director


Dr. Lukas Vaclavik

Postdoctoral fellow
Center of Food Safety and Applied Nutrition
US Food and Drug Administration

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