Applying Best-in-Class HPLC Column Technologies to the Analysis of Proteins and Biotherapeutics
This event was recorded on March 18, 2014.
The introduction of columns packed with solid-core particles has been embraced by pharmaceutical and other analysts to speed up or improve the analysis of compounds of low molecular mass. The same benefits, summarized as ‘faster or better,” are now also available to bioanalytical scientists for the analysis of proteins, peptides, and other biopolymers.
This presentation will first discuss how the benefits of solid-core technology, particularly the BIOshell Fused-Core® HPLC columns, apply to compounds of larger molecular mass with emphasis on the analysis of proteins and peptides as they relate to the development of biotherapeutics.
The second part of this webcast will show the application of LC-MS/MS to assess the pharmacokinetic (PK) properties of biotherapeutic antibodies using a stable labeled antibody internal standard (SILUMab). This standard universally supports preclinical quantification of monoclonal antibodies as well as Fc-fusion therapeutics. SILUMab can be introduced early in the workflow to reduce variability and improve accuracy.
Dr. Hillel Brandes
Principal Applications Chemist
Analytical Research Services
Dr. Kevin Ray Manager of Analytical
Research & Development
LCGC and Spectroscopy
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What quantitative technique is used in your laboratory to determine PK properties of biotherapeutics?*
Have you personally or someone in your lab used columns packed with Fused-Core or core-shell particles?*
Check what in your opinion is the greatest benefit(s) of Fused-Core or Core-shell particle columns over traditional fully porous columns packed with the same size particles?*
a. Higher efficiency at the same pressure b. Lower pressure at the same efficiency c. Faster separations d. Higher throughput e. All of the above f. None of the above
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Fused-Core is a registered trademark of Advanced Materials Technology, Inc.
BIOshell is a trademark of Sigma-Aldrich Co. LLC