HPLC for Pharmaceutical Analyses: Succeed with Sample Filtration and Optimized Water Quality
This webcast was recorded on April 09, 2014.


The entire pharmaceutical development workflow, from discovery to manufacturing and QC, relies heavily on HPLC and LC-MS analysis. Many chromatography challenges, such as poor peak resolution, poor run reproducibility, or short column life, can be traced back to improper sample preparation or mobile phase preparation. In this seminar, Vivek Joshi, PhD, of EMD Millipore reviews filtration as a sample prep technique and factors to consider while selecting appropriate filtration formats based on the stage within the pharmaceutical workflow. You will learn how to select appropriate high-throughput filtration systems commonly used in drug discovery, as well as considerations for lower-throughput approaches for manufacturing and QC operations. Dr. Joshi will also discuss tips and tricks for reducing extractables and nonspecific analyte binding. Then, Maricar Tarun-Dube, PhD, will explain the importance of ultrapure water quality in HPLC and LC–MS, demonstrating how contamination in reagent water can compromise analyses. Specifically, she will describe the challenges posed by particulates, bacteria, and organic molecules present in the mobile phase as well as strategies for overcoming these challenges.

Speakers:

Vivek Joshi, PhD

Principal Research Scientist
EMD Millipore

Maricar Tarun-Dube, PhD
Global Speaker and Scientific Writer
Life Science and Lab Water Industries

Moderator:

Laura Bush

Editorial Director
LCGC



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