Plasma Protein Calorimetry For Clinical Diagnostic Applications

Date: Tuesday, February 11, 2014
Time: 11:00 AM - 12:30 PM EST (GMT-5:00)


High sensitivity DSC analysis of blood plasma is an emerging technique for plasma proteome research and as a clinical diagnostic tool. Investigations by our group have shown that DSC plasma profiles reveal important changes in the thermal stabilities of plasma proteins. These proteins are related to disease progression and therapeutic response. The diagnostic performance of DSC for detection and monitoring of disease will be discussed, as will the underlying basis of DSC profile changes.

Nichola C. Garbett

Dr. Garbett joined the James Graham Brown Cancer Center at the University of Louisville in 2004 as a Postdoctoral Research Fellow before taking up a position as Assistant Director of the Biophysical Core Facility where she provided preclinical data for the drug development mission of the Cancer Center. In 2011, Dr. Garbett was promoted to Research Instructor to pursue her independent research ideas. Dr. Garbett received a B.Sc. and Ph.D. (both in Chemistry) from the University of Kent at Canterbury, England. She continued her education as a Postdoctoral Research Fellow at the University of Mississippi and University of Alabama at Birmingham studying the biophysical characterization of nucleic acids and their interactions. Currently, she serves as a reviewer for Drug Discovery Today, International Journal of Cancer, Nucleic Acids Research, Combinatorial Chemistry and High Throughput Screening, FEBS letters and Wiley Encyclopedia of Chemical Biology. Her research focuses on the application of biophysical approaches to medical diagnostics and the preclinical assessment of drug interactions in plasma.

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