Achieving higher throughput and productivity in monoclonal antibody characterization
Event Date: Tuesday July 16, 2013 at 8:00 am PDT/ 11:00 am EDT/ 16:00 BST/ 17:00 CEDT

There is an extensive and increasing development pipeline for monoclonal antibody (MAb) therapeutics, which, combined with advances in automation in upstream processes such as cell culture and purification process development is driving a requirement for innovative analytical tools in order to deliver greater productivity.

MAbs are complex biomolecules and during development and production of these products, it is essential to detect, characterize, and quantify impurities as well as structural variants and modifications, and to monitor product stability. This is key to demonstrating their safety and efficacy as biotherapeutics and is required by the U.S. FDA and other regulatory agencies.

Common analytical tasks include:
• Screening harvest cell culture for IgG titer using affinity chromatography
• Aggregation and fragmentation analysis using size exclusion chromatography
• Charge variant analysis using ion exchange chromatography
• Monitoring glycan and glycosylation changes and other structural modifications using LC-MS

Each of these tasks requires careful selection and optimization of the chromatographic method. In this webinar we will discuss how innovative column chemistries and techniques can be used to develop robust high throughput methods for MAb characterization.


Moderator:

Reid Paul

Multimedia Editor
BioPharm

Speakers:

Dafydd Milton

Product Manager, LC & LC-MS Columns
Chromatography Consumables
Thermo Scientific
dafydd.milton@thermofisher.com


IMPORTANT - PLEASE READ
This is a FREE streaming audio Webcast and does not require a phone line. If you have any questions regarding this Webcast, please contact Kristen Farrell, kfarrell@advanstar.com.

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