High speed, high resolution characterization of biomolecules
Event Date: March 05, 2013 at 11:00 AM EST / 8:00 AM PST

Biomolecules such as monoclonal antibodies, proteins, and oligonucleotides are increasingly being developed by pharmaceutical and biotechnology companies for a wide range of therapeutic applications. Variations in the composition of these highly complex biomolecules can dramatically affect their activity and stability as a biotherapeutic. Monitoring the stability of therapeutic biomolecules is consequently regarded as essential for demonstrating the safety and efficacy of these biologic drugs, and is expected by the FDA and other regulatory agencies.

These regulatory guidelines are likely to become stricter in the coming years and with cost containment measures expected to make a greater impact on biotechnology, the requirement for faster, more efficient characterization of biotherapeutics will become even more crucial.

Many stationary phases have been developed to deliver high resolution separations of biomolecules. Just as for small molecules, significantly faster characterization of biomolecules can be achieved using columns of shorter format and smaller particle size while maintaining the same high resolution of longer column formats. In this webinar, the use of smaller particles for high resolution and high speed variant analysis is presented.

Moderator:

Paul Reid

Multimedia Director
BioPharm International

Speaker:

Dafydd Milton

Product Manager, LC & LC-MS Columns
Chromatography Consumables
Thermo Scientific
dafydd.milton@thermofisher.com

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