Applications of Raman Spectroscopy in Biomedical Diagnostics
Event Date: October 17, 2012 at 01:00 PM EDT
In recent years, Raman spectroscopy has gained widespread recognition in biomedical research as a principal diagnostic and screening tool. This presentation will begin with an overview of the uses of Raman in a variety of biomedical applications, and then discuss one of the most active research areas for Raman biospectroscopy: cancer detection, focusing on research at the University of Utah on the development of a surface enhanced Raman scattering (SERS)–based immunoassay array for pancreatic cancer marker screening.

Pancreatic adenocarcinoma is the fourth most common cause of cancer deaths in the US with a 5-year survival rate of 4%, the lowest of any cancer. Early diagnosis of pancreatic adenocarcinoma remains elusive due to the asymptomatic development of the disease and the advanced disease state required for radiological and histopathologic determination. However, a proof-of-principle immunoassay panel using SERS has been developed. The SERS assay uses gold nanoparticles conjugated with both a secondary antibody and a Raman reporter molecule as the assay label. Matrix metallopeptidase 7 (MMP-7), a relevant and well-established marker for pancreatic adenocarcinoma, was used to develop the proof-of-concept marker panel. We will discuss the design and implementation of this first generation SERS array for pancreatic adenocarcinoma and its comparison to current clinical diagnostics.

Moderator:

Meg Evans

Managing Editor
Spectroscopy

Speakers:

Dr. Jennifer Granger

Research Scientist
Nano Institute of Utah

Dr. Michael Kayat
Vice President
B&W Tek

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