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The Hunt for Missing Heritability: Challenges and Opportunities for Novel Locus Discovery in Non-European Populations

Event Date: January 31, 2012 12 noon Eastern, 9 a.m. Pacific, 5 p.m. UK

Sponsored by Affymetrix

Characterizing the genetics of complex diseases has, to date, focused on common variants and predominantly on populations of European descent. GWAS methodologies have been successful in uncovering novel susceptibility loci for common disorders but the heritability of many disorders remains to be explained. Now, a growing number of investigators are looking beyond European cohorts to study common and rare variants in populations around the world, including African, Asian, and other ancestries in the hunt for novel susceptibility genes.

  • Discuss how population genetics integrates with the genetics of complex disease to reveal novel disease genes
  • Describe how the discovery of population-specific rare variants expands our understanding of complex diseases
  • Explain the importance of population-optimized strategies and tools that account for differences in genetic diversity and population admixture
  • Answer your questions live!

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1. Which genetic applications and populations are you studying? (Check all that apply) *Complex trait genetics
Mendelian trait genetics
Population genetics
Other genetic applications
African/African American ancestries
East Asian ancestries
European ancestries
Latino ancestries
Multi-ethnic cohorts
Other populations (please specify below)
I'm not currently studying populations
Please specify the other population(s) used:
2. How strongly do you agree or disagree with the following statement: "GWAS studies in non-European populations detect fewer associations due to the European bias of commercial genotyping arrays." (Check one) *Strongly agree
Strongly disagree
I dont know
3. When will you start your next genotyping project? (Check one) *Less than 3 months
3 to 6 months
6 months to 1 year
1 to 2 years
More than 2 years
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