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ECTS/IBMS Cortical Bone Modeling and Remodeling in the Adult Skeleton
Cortical bone undergoes both modeling (resorption and formation occurring independently of each other at different sites) and remodeling (coupled and sequential resorption and formation occurring at the same site). Modeling and remodeling occur on both the endocortical and periosteal surfaces of the cortex, whereas within the cortex only remodeling – referred to as Haversian remodeling - takes place. Disruptions in the modeling process during growth results in deformed bones, the classic case of which is the Erlenmeyer flask deformity. Modeling also occurs in adults, primarily in response to changes in mechanical loading. Recently, however, newer drugs used to treat osteoporosis have been shown to be either permissive to modeling or to stimulate it. This has rekindled interest in the topic of modeling in the adult skeleton and in its potential for therapeutic manipulation.
David W. Dempster
Speakers:
 | David W. Dempster David Dempster is Professor of Clinical Pathology and Cell Biology at Columbia University in New York and a Senior Research Fellow at the Regional Bone Center of Helen Hayes Hospital, West Haverstraw, New York. Dr. Dempster is a Past President of the International Society of Bone Morphometry and is a Fellow of the Royal Microscopical Society. Dr. Dempster is an Associate Editor of Osteoporosis International, and serves on the editorial boards of Bone and the Journal of Clinical Densitometry. Dr. Dempster has published over 250 research papers on the pathophysiology and treatment of bone disease. |
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| Moderator | |
 | Bente Lomholt Langdahl Bente Langdahl graduated from medical school at Aarhus University in 1988 and did clinical training in internal medicine and endocrinology at Aarhus University Hospital. Bente Langdahl received her PhD at Aarhus University in 1995: “Investigations on a possible pathogenic role of thyroid hormones in postmenopausal osteoporosis” and received a DMSc at the same university in 2004: “The genetics of bone mass and risk of osteoporotic fractures”. In 2004 Bente Langdahl was appointed consultant at the department of Endocrinology and Internal Medicine at Aarhus University Hospital and research lecturer at Aarhus University. In 2012 Bente Langdahl was appointed professor at Aarhus University. Bente Langdahl’s main research interests are identification and further investigation of genetic variants that imply increased risk of osteoporotic fractures, osteogenesis imperfecta in adult patients, interactions between fat and bone tissues with a special interest in the PPARgamma pathway, the impact of diabetes on bone health, the effects of vitamin D and K on bone metabolism, and the development of new treatments for osteoporosis.
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